Endocrine Abstracts

Hypothalamic neuropeptide PACAP is a potent endogenous stimulator of adenylate cyclase synthesis in gonadotrope cells. Previously we found that, in contrast to GnRH, also Cu–GnRH complex is able to induce cAMP/PKA pathway activity.The aim of the study was to determine whether Cu–GnRH can act via GnRH-R and/or PAC-1 receptors to stimulate cAMP/PKA intracellular signaling. Moreover, we compared PACAP and Cu–GnRH ability to activate cGMP/PKG ...

Introduction: VPA, antiepileptic drug, may cause a number of side effects including reproductive deficits in humans. Previously we found that VPA (1 μM) may suppress GnRH-stimulated release of LH from rat anterior pituitary cells in vitro without affecting its basal secretion (Neuroendocrinol Lett 2011 32 101–106). However mechanism of VPA suppressive activity is still unknown. Since pharmacological effects of VPA require GnRH-R activation, the m...

Introduction: Graves’ disease during pregnancy may cause maternal or neonatal complications, including arrhythmia, thyroid storm, congenital anomalies and neonatal thyroid dysfunction (TD). The optimal timing and frequency of TRAb measurement in pregnant women with a history of TD, and whether fetal monitoring could be limited to those with a strongly positive TRAb, is unclear.Methods: Retrospective case note review of women with elevated TRAb (>1 i...